Production of shikimic acid from Escherichia coli through chemically inducible chromosomal evolution and cofactor metabolic engineering

BACKGROUND: Shikimic acid (SA) produced from the seeds of Chinese star anise (Illicium verum) is a key intermediate for the synthesis of neuraminidase inhibitors such as oseltamivir (Tamiflu®), an anti-influenza drug. However, plants cannot deliver a stable supply of SA. To avoid the resulting short...

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Main Authors: Cui, Yan-Yan, Ling, Chen, Zhang, Yuan-Yuan, Huang, Jian, Liu, Jian-Zhong
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923554/
https://ncbi.nlm.nih.gov/pubmed/24512078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-13-21
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