EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1 (NF1). EGFR overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression promotes mous...

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Detalhes bibliográficos
Main Authors: Wu, Jianqiang, Patmore, Deanna M., Jousma, Edwin, Eaves, David W., Breving, Kimberly, Patel, Ami V., Schwartz, Eric B., Fuchs, James R., Cripe, Timothy P., Stemmer-Rachamimov, Anat O., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923530/
https://ncbi.nlm.nih.gov/pubmed/23318430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.579
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