Insertional mutagenesis identifies a STAT3/Arid1b/β-catenin pathway driving neurofibroma initiation

To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (Nf1) neurofibroma, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway which becomes active in the context of Nf1 loss. Genetic delet...

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Publicado no:Cell Rep
Main Authors: Wu, Jianqiang, Keng, Vincent, Patmore, Deanna M., Kendall, Jed K., Patel, Ami V., Jousma, Edwin, Jessen, Walter J., Choi, Kwangmin, Tschida, Barbara R., Silverstein, Kevin A. T., Fan, Danhua, Schwartz, Eric B., Fuchs, James R., Zou, Yuanshu, Kim, Mi-Ok, Dombi, Eva, Levy, David E., Huang, Gang, Cancelas, Jose A., Stemmer-Rachamimov, Anat O., Spinner, Robert J., Largaespada, David A., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782770/
https://ncbi.nlm.nih.gov/pubmed/26904939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.074
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