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Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible

Tissue hypoxia plays a key role in establishing an immunosuppressive environment in vivo by, among other effects, increasing the level of extracellular adenosine, which then signals through A2A adenosine receptor (A2AR) to elicit its immunosuppressive effect. Although the important role of the adeno...

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Detalhes bibliográficos
Main Authors: Ohta, Akio, Madasu, Manasa, Subramanian, Meenakshi, Kini, Radhika, Jones, Graham, Choukèr, Alexander, Ohta, Akiko, Sitkovsky, Michail
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923523/
https://ncbi.nlm.nih.gov/pubmed/24150242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxt045
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