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Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible

Tissue hypoxia plays a key role in establishing an immunosuppressive environment in vivo by, among other effects, increasing the level of extracellular adenosine, which then signals through A2A adenosine receptor (A2AR) to elicit its immunosuppressive effect. Although the important role of the adeno...

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Hlavní autoři: Ohta, Akio, Madasu, Manasa, Subramanian, Meenakshi, Kini, Radhika, Jones, Graham, Choukèr, Alexander, Ohta, Akiko, Sitkovsky, Michail
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923523/
https://ncbi.nlm.nih.gov/pubmed/24150242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxt045
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