The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells

TIF1β is a transcriptional corepressor that recruits repressive chromatin modifiers to target genes. Its biological function and physiological targets in somatic stem cells remain largely unknown. Here, we show that TIF1β is essential for the maintenance of hematopoietic stem cells (HSCs). Deletion...

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Detalhes bibliográficos
Main Authors: Miyagi, Satoru, Koide, Shuhei, Saraya, Atsunori, Wendt, George R., Oshima, Motohiko, Konuma, Takaaki, Yamazaki, Satoshi, Mochizuki-Kashio, Makiko, Nakajima-Takagi, Yaeko, Wang, Changshan, Chiba, Tetsuhiro, Kitabayashi, Issay, Nakauchi, Hiromitsu, Iwama, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923190/
https://ncbi.nlm.nih.gov/pubmed/24527388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.12.008
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