Bmi1 Confers Resistance to Oxidative Stress on Hematopoietic Stem Cells

BACKGROUND: The polycomb-group (PcG) proteins function as general regulators of stem cells. We previously reported that retrovirus-mediated overexpression of Bmi1, a gene encoding a core component of polycomb repressive complex (PRC) 1, maintained self-renewing hematopoietic stem cells (HSCs) during...

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Autors principals: Nakamura, Shunsuke, Oshima, Motohiko, Yuan, Jin, Saraya, Atsunori, Miyagi, Satoru, Konuma, Takaaki, Yamazaki, Satoshi, Osawa, Mitsujiro, Nakauchi, Hiromitsu, Koseki, Haruhiko, Iwama, Atsushi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350495/
https://ncbi.nlm.nih.gov/pubmed/22606246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036209
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