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The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells

TIF1β is a transcriptional corepressor that recruits repressive chromatin modifiers to target genes. Its biological function and physiological targets in somatic stem cells remain largely unknown. Here, we show that TIF1β is essential for the maintenance of hematopoietic stem cells (HSCs). Deletion...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Satoru Miyagi, Shuhei Koide, Atsunori Saraya, George R. Wendt, Motohiko Oshima, Takaaki Konuma, Satoshi Yamazaki, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Issay Kitabayashi, Hiromitsu Nakauchi, Atsushi Iwama
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014-02-01
Schriftenreihe:Stem Cell Reports
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2213671113001768
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