Stoichiometry of GTP hydrolysis and tubulin polymerization.

Microtubule formation from lamb brain tubulin isolated by affinity chromatography and freed of exchangeable nucleotide requires GTP for maximal rate and extent of polymerization. The nucleotide analogs guanylylmethylenediphosphate and guanylylimidodiphosphate fail to replace GTP; in addition, neithe...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Maccioni, R, Seeds, N W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1977
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392309/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/191810/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.2.462
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