Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity

Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel monoclonal antibody to the INSR. Biophysical studies demonstrated that XMetS bound to the human and mouse INSR with picomolar affinity. Unlike mo...

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Autors principals: Corbin, John A., Bhaskar, Vinay, Goldfine, Ira D., Bedinger, Daniel H., Lau, Angela, Michelson, Kristen, Gross, Lisa M., Maddux, Betty A., Kuan, Hua F., Tran, Catarina, Lao, Llewelyn, Handa, Masahisa, Watson, Susan R., Narasimha, Ajay J., Zhu, Shirley, Levy, Raphael, Webster, Lynn, Wijesuriya, Sujeewa D., Liu, Naichi, Wu, Xiaorong, Chemla-Vogel, David, Lee, Steve R., Wong, Steve, Wilcock, Diane, White, Mark L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922975/
https://ncbi.nlm.nih.gov/pubmed/24533136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088684
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