Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity

Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel monoclonal antibody to the INSR. Biophysical studies demonstrated that XMetS bound to the human and mouse INSR with picomolar affinity. Unlike mo...

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Bibliografiska uppgifter
Huvudupphovsmän: Corbin, John A., Bhaskar, Vinay, Goldfine, Ira D., Bedinger, Daniel H., Lau, Angela, Michelson, Kristen, Gross, Lisa M., Maddux, Betty A., Kuan, Hua F., Tran, Catarina, Lao, Llewelyn, Handa, Masahisa, Watson, Susan R., Narasimha, Ajay J., Zhu, Shirley, Levy, Raphael, Webster, Lynn, Wijesuriya, Sujeewa D., Liu, Naichi, Wu, Xiaorong, Chemla-Vogel, David, Lee, Steve R., Wong, Steve, Wilcock, Diane, White, Mark L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922975/
https://ncbi.nlm.nih.gov/pubmed/24533136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088684
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