Targeting Wee1 for the treatment of pediatric high-grade gliomas

BACKGROUND: We investigated the efficacy of the Wee1 inhibitor MK-1775 in combination with radiation for the treatment of pediatric high-grade gliomas (HGGs), including diffuse intrinsic pontine gliomas (DIPGs). METHODS: Gene expression analysis was performed for 38 primary pediatric gliomas (3 grad...

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Hlavní autoři: Mueller, Sabine, Hashizume, Rintaro, Yang, Xiaodong, Kolkowitz, Ilan, Olow, Aleksandra K., Phillips, Joanna, Smirnov, Ivan, Tom, Maxwell W., Prados, Michael D., James, C. David, Berger, Mitchel S., Gupta, Nalin, Haas-Kogan, Daphne A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922515/
https://ncbi.nlm.nih.gov/pubmed/24305702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not220
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