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Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. This canonical Notch signaling pathway has been documented to influenc...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Frontiers Media S.A.
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3921607/ https://ncbi.nlm.nih.gov/pubmed/24611064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00054 |
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