Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells

Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. This canonical Notch signaling pathway has been documented to influenc...

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Bibliographic Details
Main Authors: Dongre, Anushka, Surampudi, Lalitha, Lawlor, Rebecca G., Fauq, Abdul H., Miele, Lucio, Golde, Todd E., Minter, Lisa M., Osborne, Barbara A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921607/
https://ncbi.nlm.nih.gov/pubmed/24611064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00054
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