Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

Severe aplastic anemia (AA) is a bone marrow (BM) failure (BMF) disease frequently caused by aberrant immune destruction of blood progenitors. Although a Th1-mediated pathology is well described for AA, molecular mechanisms driving disease progression remain ill defined. The NOTCH signaling pathway...

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Main Authors: Roderick, Justine E., Gonzalez-Perez, Gabriela, Kuksin, Christina Arieta, Dongre, Anushka, Roberts, Emily R., Srinivasan, Janani, Andrzejewski, Chester, Fauq, Abdul H., Golde, Todd E., Miele, Lucio, Minter, Lisa M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698520/
https://ncbi.nlm.nih.gov/pubmed/23733784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112615
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