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CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia
Aplastic anemia (AA) is a disease characterized by T-cell–mediated destruction of bone marrow (BM) hematopoietic stem and progenitor cells. Physiologically, T cells migrate to the BM in response to chemokines, such as SDF-1α, the ligand for CXCR4. However, how T cells traffic to the BM in AA is poor...
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| Udgivet i: | Blood |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375106/ https://ncbi.nlm.nih.gov/pubmed/25647836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594796 |
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