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CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia
Aplastic anemia (AA) is a disease characterized by T-cell–mediated destruction of bone marrow (BM) hematopoietic stem and progenitor cells. Physiologically, T cells migrate to the BM in response to chemokines, such as SDF-1α, the ligand for CXCR4. However, how T cells traffic to the BM in AA is poor...
Guardat en:
| Publicat a: | Blood |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375106/ https://ncbi.nlm.nih.gov/pubmed/25647836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594796 |
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