Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells

Notch and its ligands have been implicated in the regulation and differentiation of various CD4(+) T-helper cells. Regulatory T cells (T(regs)), which express the transcription factor Foxp3, suppress aberrant immune responses that are typically associated with autoimmunity or excessive inflammation....

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Detalhes bibliográficos
Main Authors: Samon, Jeremy B., Champhekar, Ameya, Minter, Lisa M., Telfer, Janice C., Miele, Lucio, Fauq, Abdul, Das, Pritam, Golde, Todd E., Osborne, Barbara A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518888/
https://ncbi.nlm.nih.gov/pubmed/18550850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144980
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