NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome

T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the membrane-tethered CBM complex, comprising CARMA1, BCL10, and MALT1, which is required for TCR-mediated NF-κB activation. TCR signaling has been s...

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Detalhes bibliográficos
Main Authors: Shin, Hyun Mu, Tilahun, Mulualem E., Cho, Ok Hyun, Chandiran, Karthik, Kuksin, Christina Arieta, Keerthivasan, Shilpa, Fauq, Abdul H., Golde, Todd E., Miele, Lucio, Thome, Margot, Osborne, Barbara A., Minter, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033603/
https://ncbi.nlm.nih.gov/pubmed/24904593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00249
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