Notch signaling mediates G(1)/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

Notch signaling plays a role in normal lymphocyte development and function. Activating Notch1-mutations, leading to aberrant downstream signaling, have been identified in human T-cell acute lymphoblastic leukemia (T-ALL). While this highlights the contribution of Notch signaling to T-ALL pathogenesi...

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Detalhes bibliográficos
Main Authors: Joshi, Ila, Minter, Lisa M., Telfer, Janice, Demarest, Renée M., Capobianco, Anthony J., Aster, Jon C., Sicinski, Piotr, Fauq, Abdul, Golde, Todd E., Osborne, Barbara A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647664/
https://ncbi.nlm.nih.gov/pubmed/19001083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-147967
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