Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis

Cytotoxic lymphocyte protease granzyme M (GrM) is a potent inducer of tumor cell death. The apoptotic phenotype and mechanism by which it induces cell death, however, remain poorly understood and controversial. Here, we show that GrM-induced cell death was largely caspase-dependent with various hall...

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Detaylı Bibliyografya
Asıl Yazarlar: de Poot, S A H, Lai, K W, van der Wal, L, Plasman, K, Van Damme, P, Porter, A C, Gevaert, K, Bovenschen, N
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2014
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921589/
https://ncbi.nlm.nih.gov/pubmed/24185622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.155
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