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Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis
Cytotoxic lymphocyte protease granzyme M (GrM) is a potent inducer of tumor cell death. The apoptotic phenotype and mechanism by which it induces cell death, however, remain poorly understood and controversial. Here, we show that GrM-induced cell death was largely caspase-dependent with various hall...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3921589/ https://ncbi.nlm.nih.gov/pubmed/24185622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.155 |
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