USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

Neuroblastoma (NB) is a common pediatric cancer and contributes to more than 15% of all pediatric cancer-related deaths. Unlike adult tumors, recurrent somatic mutations in NB, such as tumor protein 53 (p53) mutations, occur with relative paucity. In addition, p53 downstream function is intact in NB...

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Detalhes bibliográficos
Main Authors: Fan, Y-H, Cheng, J, Vasudevan, S A, Dou, J, Zhang, H, Patel, R H, Ma, I T, Rojas, Y, Zhao, Y, Yu, Y, Shohet, J M, Nuchtern, J G, Kim, E S, Yang, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920959/
https://ncbi.nlm.nih.gov/pubmed/24136231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.400
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