A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function is largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, is an E2 ubiquitin-conjugating enzyme that promotes formation of mono...

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Detalhes bibliográficos
Main Authors: Cheng, J, Fan, Y-H, Xu, X, Zhang, H, Dou, J, Tang, Y, Zhong, X, Rojas, Y, Yu, Y, Zhao, Y, Vasudevan, S A, Nuchtern, J G, Kim, E S, Chen, X, Lu, F, Yang, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944268/
https://ncbi.nlm.nih.gov/pubmed/24556694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.54
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