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INHIBITION OF USP7 ACTIVITY SELECTIVELY ELIMINATES SENESCENT CELLS IN A P53-DEPENDENT MANNER

Accumulation of senescent cells (SCs) is a causal factor of various age-related diseases and also plays a role in some of the side effects induced by chemotherapy. Pharmacological elimination of SCs (senolysis) has the potential to be developed as a novel therapeutic strategy to treat these diseases...

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Publicat a:Innov Aging
Autors principals: He, Y, Li, W, Lyu, D, Zhang, X, Campisi, J, Zheng, G, Zhou, D
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239410/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy031.3295
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