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INHIBITION OF USP7 ACTIVITY SELECTIVELY ELIMINATES SENESCENT CELLS IN A P53-DEPENDENT MANNER
Accumulation of senescent cells (SCs) is a causal factor of various age-related diseases and also plays a role in some of the side effects induced by chemotherapy. Pharmacological elimination of SCs (senolysis) has the potential to be developed as a novel therapeutic strategy to treat these diseases...
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| Publicado en: | Innov Aging |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6239410/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy031.3295 |
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