APR-246/PRIMA-1(MET) inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

The low-molecular-weight compound APR-246 (PRIMA-1(MET)) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. We show here that APR-246 also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance. APR-246 inh...

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Autors principals: Peng, X, Zhang, M-Q-Z, Conserva, F, Hosny, G, Selivanova, G, Bykov, V J N, Arnér, E S J, Wiman, K G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920950/
https://ncbi.nlm.nih.gov/pubmed/24157875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.417
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