The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21(WAF1/CIP1)

The p90 ribosomal S6 kinase (RSK) family is a group of highly conserved Ser/Thr kinases that promote cell proliferation, growth, motility and survival. As they are almost exclusively activated downstream of extracellular signal-regulated kinases 1 and 2 (ERK1/2), therapeutic intervention by RSK inhi...

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Detaylı Bibliyografya
Asıl Yazarlar: Neise, D, Sohn, D, Stefanski, A, Goto, H, Inagaki, M, Wesselborg, S, Budach, W, Stühler, K, Jänicke, R U
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920941/
https://ncbi.nlm.nih.gov/pubmed/24136223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.386
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