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Identification of Functionally Relevant Lysine Residues That Modulate Human Farnesoid X Receptor Activation

Base amino acid lysine residues play an important role in regulation of nuclear receptors [e.g., farnesyl X receptor (FXR)], leading to enhanced or suppressed biologic activity. To understand the molecular mechanisms and the subsequent effects in modulating FXR functions in diverse biologic processe...

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Hlavní autoři: Sun, An-Qiang, Luo, Yuhuan, Backos, Donald S., Xu, Shuhua, Balasubramaniyan, Natarajan, Reigan, Philip, Suchy, Frederick J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920091/
https://ncbi.nlm.nih.gov/pubmed/23462506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.084772
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