The Membrane Protein, ATP8B1, Signals Through Protein Kinase C-Zeta to Activate the Farnesoid X Receptor

BACKGROUND: Prior loss-of-function analyses revealed that ATP8B1 (FIC1) post-translationally activated the Farnesoid X-Receptor (FXR). METHODS: Mechanisms underlying this regulation are elaborated upon by these gain-of-function studies in UPS cells, which lack endogenous FIC1 expression. FXR functio...

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Autores principales: Frankenberg, Tamara, Miloh, Tamir, Chen, Frank Y., Ananthanarayanan, Meena, Sun, An-Qiang, Balasubramaniyan, Natarajan, Arias, Irwin, Setchell, Kenneth D. R., Suchy, Frederick J., Shneider, Benjamin L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774894/
https://ncbi.nlm.nih.gov/pubmed/18668687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22431
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