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Brain Efflux Index To Investigate the Influence of Active Efflux on Brain Distribution of Pemetrexed and Methotrexate

Antifolates, in particular methotrexate (MTX), have been widely used in the treatment of primary and secondary tumors of the central nervous system (CNS). Pemetrexed (PMX) is a novel antifolate that also exhibits potent antitumor activity against CNS malignancies. Studies have shown that brain distr...

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Autors principals: Li, Li, Agarwal, Sagar, Elmquist, William F.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920090/
https://ncbi.nlm.nih.gov/pubmed/23297298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.049254
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