Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria.
DNA repair alkyltransferases protect organisms against the cytotoxic, mutagenic, and carcinogenic effects of alkylating agents by transferring alkyl adducts from DNA to an active cysteine on the protein, thereby restoring the native DNA structure. We used random sequence substitutions to gain struct...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39200/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650230/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.6124 |
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