Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria.

DNA repair alkyltransferases protect organisms against the cytotoxic, mutagenic, and carcinogenic effects of alkylating agents by transferring alkyl adducts from DNA to an active cysteine on the protein, thereby restoring the native DNA structure. We used random sequence substitutions to gain struct...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Christians, F C, Loeb, L A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39200/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650230/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.6124
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