p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment

Hematopoiesis is regulated by components of the microenvironment, so-called niche. Here, we show that p190-B GTPase Activating Protein (p190-B) deletion in mice causes hematopoietic failure during ontogeny, in p190-B(−/−) fetal liver and bones, and in p190-B(+/−) adult bones and spleen. These defect...

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Autori principali: Raman, Rachna, Kumar, Rupali Sani, Hinge, Ashwini, Kumar, Sachin, Nayak, Ramesh, Xu, Juying, Szczur, Kathleen, Cancelas, Jose A., Filippi, Marie-Dominique
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919554/
https://ncbi.nlm.nih.gov/pubmed/23563238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.103
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