p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choices remain ill-defined. Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-β-p38(MAPK) balances HSPC self-renewal and differentiation. Upon transplantation, HSPCs express high amounts of bioactive TGF-β1 p...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Hinge, Ashwini, Xu, Juying, Javier, Jose, Mose, Eucabeth, Kumar, Sachin, Kapur, Reuben, Srour, Edward F., Malik, Punam, Aronow, Bruce J., Filippi, Marie-Dominique
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309857/
https://ncbi.nlm.nih.gov/pubmed/28176763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14382
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