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The effect of the hydrophobic environment on the retro-aldol reaction: Comparison to a computationally-designed enzyme

Recent work on a computationally-designed retroaldolase RA-61 suggested that most of the rate-acceleration brought about by this enzyme was due to non-specific interactions with the aromatic substrate. To provide a benchmark for the role of non-specific interactions in this system, we measured the s...

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Hlavní autoři: Schmidt, Joshua, Ehasz, Clayton, Epperson, Michael, Klas, Kimberly, Wyatt, Justin, Hennig, Mirko, Forconi, Marcello
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919508/
https://ncbi.nlm.nih.gov/pubmed/24189834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob41898g
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