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Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules
Deoxycytidine kinase (dCK) is a key enzyme in the nucleoside salvage pathway that is also required for the activation of several anticancer and antiviral nucleoside analog prodrugs. Additionally, dCK has been implicated in immune disorders and has been found to be overexpressed in several cancers. T...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
International Union of Crystallography
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919262/ https://ncbi.nlm.nih.gov/pubmed/24419380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004713025030 |
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