Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) repairs 3’-blocking DNA lesions by catalytically hydrolyzing the tyrosyl-DNA-phosphodiester bond of trapped topoisomerase I (Top1) cleavage complexes (Top1cc). It also removes 3’-blocking residues derived from oxidative damage or incorporation of chain terminat...

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Detalhes bibliográficos
Main Authors: Gao, Rui, Das, Benu Brata, Chatterjee, Raghunath, Abaan, Ogan, Agama, Keli, Matuo, Renata, Vinson, Charles, Meltzer, Paul S., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919147/
https://ncbi.nlm.nih.gov/pubmed/24355542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.09.001
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