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Dynamics transitions at the outer vestibule of the KcsA potassium channel during gating

In K(+) channels, the selectivity filter, pore helix, and outer vestibule play a crucial role in gating mechanisms. The outer vestibule is an important structurally extended region of KcsA in which toxins, blockers, and metal ions bind and modulate the gating behavior of K(+) channels. Despite its f...

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Autori principali: Raghuraman, H., Islam, Shahidul M., Mukherjee, Soumi, Roux, Benoit, Perozo, Eduardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918809/
https://ncbi.nlm.nih.gov/pubmed/24429344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314875111
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