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Side chain dynamics of carboxyl and carbonyl groups in the catalytic function of Escherichia coli ribonuclease H
Many proteins use Asx and Glx (x = n, p, or u) side chains as key functional groups in enzymatic catalysis and molecular recognition. In this study, NMR spin relaxation experiments and molecular dynamics (MD) simulations are used to measure the dynamics of the side chain amide and carboxyl groups, (...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3918730/ https://ncbi.nlm.nih.gov/pubmed/24219366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja409479y |
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