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Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction
DNA polymerase β (pol β) is a bifunctional enzyme widely studied for its roles in base excision DNA repair where one key function is gap-filling DNA synthesis. In spite of significant progress in recent years, the atomic level mechanism of the DNA synthesis reaction has remained poorly understood. B...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3918438/ https://ncbi.nlm.nih.gov/pubmed/23647366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403842j |
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