A non-canonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia (AML)

PURPOSE: DAPK1, a tumor suppressor, is a rate-limiting effector in an ER stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in several tumors. A mechanistic basis for epigenetic/transcriptional repression of DAPK1 was investigated in certain forms of AML with poor progno...

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Main Authors: Shanmugam, Rajasubramaniam, Gade, Padmaja, Wilson-Weekes, Annique, Sayar, Hamid, Suvannasankha, Attaya, Goswami, Chirayu, Li, Lang, Gupta, Sushil, Cardoso, Angelo A., Baghdadi, Tareq Al, Sargent, Katie J., Cripe, Larry D., Kalvakolanu, Dhananjaya V., Boswell, H. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918433/
https://ncbi.nlm.nih.gov/pubmed/22096027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3022
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