A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis

Dicer is as an RNase III enzyme essential for the maturation of the majority of microRNAs. Recent studies have revealed down-regulation or hemizygous loss of Dicer in many tumor models and demonstrated that suppressing Dicer activity enhances tumorigenic activities of lung and breast cancer cells, w...

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Главные авторы: Zhang, Boyu, Chen, Hua, Zhang, Li, Dakhova, Olga, Zhang, Yiqun, Lewis, Michael T, Creighton, Chad J, Ittmann, Michael M, Xin, Li
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916938/
https://ncbi.nlm.nih.gov/pubmed/23851498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.281
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