Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity

The role of Notch signaling in the maintenance of adult murine prostate epithelial homeostasis remains unclear. We found that Notch ligands are mainly expressed within the basal cell lineage, while active Notch signaling is detected in both the prostate basal and luminal cell lineages. Disrupting th...

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Detalhes bibliográficos
Main Authors: Valdez, Joseph M, Zhang, Li, Su, Qingtai, Dakhova, Olga, Zhang, Yiqun, Shahi, Payam, Spencer, David M, Creighton, Chad J, Ittmann, Michael M, Xin, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490134/
https://ncbi.nlm.nih.gov/pubmed/23122291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.07.003
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