A Missense Mutation in Rev7 Disrupts Formation of Polζ, Impairing Mouse Development and Repair of Genotoxic Agent-induced DNA Lesions

Repro22 is a mutant mouse produced via N-ethyl-N-nitrosourea-induced mutagenesis that shows sterility with germ cell depletion caused by defective proliferation of primordial germ cells, decreased body weight, and partial lethality during embryonic development. Using a positional cloning strategy, w...

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Dades bibliogràfiques
Autors principals: Khalaj, Maryam, Abbasi, Abdolrahim, Yamanishi, Hiroshi, Akiyama, Kouyou, Wakitani, Shuso, Kikuchi, Sotaro, Hirose, Michiko, Yuzuriha, Misako, Magari, Masaki, Degheidy, Heba A., Abe, Kuniya, Ogura, Atsuo, Hashimoto, Hiroshi, Kunieda, Tetsuo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916577/
https://ncbi.nlm.nih.gov/pubmed/24356953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.514752
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