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Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor
GPR35 is a G protein-coupled receptor expressed in the immune, gastrointestinal, and nervous systems in gastric carcinomas and is implicated in heart failure and pain perception. We investigated residues in GPR35 responsible for ligand activation and the receptor structure in the active state. GPR35...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3916562/ https://ncbi.nlm.nih.gov/pubmed/24347166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508382 |
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