Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

Cytochrome P450 46A1 (CYP46A1) is a brain-specific cholesterol 24-hydroxylase responsible for the majority of cholesterol elimination from the brain. Genetically increased CYP46A1 expression in mice leads to improved cognition and decreases manifestations of Alzheimer disease. We found that four pha...

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Main Authors: Mast, Natalia, Li, Yong, Linger, Marlin, Clark, Matthew, Wiseman, Jeffrey, Pikuleva, Irina A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Lipids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916554/
https://ncbi.nlm.nih.gov/pubmed/24352658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532846
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