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Cholesterol Hydroperoxides as Substrates for Cholesterol-Metabolizing Cytochromes P450 and Alternative Sources of 25-Hydroxycholesterol and other Oxysterols
The interaction of primary autoxidation products of cholesterol, 25- and 20ξ-hydroperoxides, with the four principal cholesterol-metabolizing cytochrome P450 enzymes is reported. Addition of cholesterol 25-hydroperoxide to CYP27A1 and CYP11A1 induced well-defined spectral changes while generating 25...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Angew Chem Int Ed Engl |
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| Κύριοι συγγραφείς: | , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4578806/ https://ncbi.nlm.nih.gov/pubmed/26230055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201505002 |
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