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Cholesterol Hydroperoxides as Substrates for Cholesterol-Metabolizing Cytochromes P450 and Alternative Sources of 25-Hydroxycholesterol and other Oxysterols

The interaction of primary autoxidation products of cholesterol, 25- and 20ξ-hydroperoxides, with the four principal cholesterol-metabolizing cytochrome P450 enzymes is reported. Addition of cholesterol 25-hydroperoxide to CYP27A1 and CYP11A1 induced well-defined spectral changes while generating 25...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: van Lier, Johan E., Mast, Natalia, Pikuleva, Irina A.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578806/
https://ncbi.nlm.nih.gov/pubmed/26230055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201505002
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