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Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo
Cytochrome P450 27A1 (CYP27A1) is a ubiquitous enzyme that hydroxylates cholesterol and other sterols. Complete CYP27A1 deficiency owing to genetic mutations is detrimental to human health, whereas 50% of activity retention is not and does not affect the whole body cholesterol levels. CYP27A1 is con...
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| Publicado en: | Mol Pharmacol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749491/ https://ncbi.nlm.nih.gov/pubmed/29192124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110742 |
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