Altered Expression of Small Heterodimer Partner Governs Cytochrome P450 (CYP) 2D6 Induction during Pregnancy in CYP2D6-humanized Mice

Substrates of a major drug-metabolizing enzyme CYP2D6 display increased elimination during pregnancy, but the underlying mechanisms are unknown in part due to a lack of experimental models. Here, we introduce CYP2D6-humanized (Tg-CYP2D6) mice as an animal model where hepatic CYP2D6 expression is inc...

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Bibliographic Details
Main Authors: Koh, Kwi Hye, Pan, Xian, Shen, Hong-Wu, Arnold, Samuel L. M., Yu, Ai-Ming, Gonzalez, Frank J., Isoherranen, Nina, Jeong, Hyunyoung
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916516/
https://ncbi.nlm.nih.gov/pubmed/24318876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526798
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