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Exogenous OX40 stimulation during LCMV infection impairs follicular T helper cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1
T cell co-stimulation is a key component of adaptive immunity to viral infection but has also been associated with pathology due to excessive or altered T cell activity. We recently demonstrated that the TNFR family co-stimulatory molecule OX40 (CD134) is critically required to sustain antiviral T c...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3915873/ https://ncbi.nlm.nih.gov/pubmed/24101548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300013 |
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