Exogenous OX40 stimulation during LCMV infection impairs follicular T helper cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1

T cell co-stimulation is a key component of adaptive immunity to viral infection but has also been associated with pathology due to excessive or altered T cell activity. We recently demonstrated that the TNFR family co-stimulatory molecule OX40 (CD134) is critically required to sustain antiviral T c...

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Hlavní autoři: Boettler, Tobias, Choi, Youn Soo, Salek-Ardakani, Shahram, Cheng, Yang, Moeckel, Friedrich, Croft, Michael, Crotty, Shane, von Herrath, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915873/
https://ncbi.nlm.nih.gov/pubmed/24101548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300013
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