Exploring Natural Product Chemistry and Biology with Multicomponent Reactions. 5. Discovery of a Novel Tubulin-Targeting Scaffold Derived from the Rigidin Family of Marine Alkaloids

We developed synthetic chemistry to access the marine alkaloid rigidins and over forty synthetic analogues based on the 7-deazaxanthine, 7-deazaadenine, 7-deazapurine and 7-deazahypoxanthine skeletons. Analogues based on the 7-deazahypoxanthine skeleton exhibited nanomolar potencies against cell lin...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Frolova, Liliya V., Magedov, Igor V., Romero, Anntherese E., Karki, Menuka, Otero, Isaiah, Hayden, Kathryn, Evdokimov, Nikolai M., Banuls, Laetitia Moreno Y., Rastogi, Shiva K., Smith, W. Ross, Lu, Shi-Long, Kiss, Robert, Shuster, Charles B., Hamel, Ernest, Betancourt, Tania, Rogelj, Snezna, Kornienko, Alexander
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2013
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915529/
https://ncbi.nlm.nih.gov/pubmed/23927793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400711t
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια